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Kamis, 23 September 2010

Ice as a protocellular medium for RNA replication

KeSimpulan - Sebuah transisi penting asal usul kehidupan adalah informasi kemampuan replikasi diri dan kompartementalisasi di dalam struktur protocellular.

Peneliti menunjukkan bahwa sifat fisikokimia es sebagai media sederhana yang luas pada masa awal Bumi bisa menjadi mediasi transisi sebelum munculnya protocells.

Es tidak hanya mempromosikan aktivitas sebuah ribozyme polimerase RNA, tetapi juga melindungi dari degradasi hidrolitik, memungkinkan sintesis produk replikasi yang sangat panjang. Es selanjutnya mengurangi ketergantungan replikasi RNA pada konsentrasi substrat prebiotically, sambil memberikan kompartementalisasi quasicellular dalam mikro rumit dari fase eutektik.

Hasil, peneliti mendukung peran yang lebih luas dari es sebagai kecenderungan lingkungan yang mempromosikan semua langkah dari sintesis prebiotik dengan munculnya replikasi diri RNA dan evolusi precellular Charles Darwin.

Penulis :

James Attwater1
Aniela Wochner1
Vitor B. Pinheiro1
Alan Coulson1
Philipp Holliger1

Afiliasi :

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

DOI:10.1038/ncomms1076
Penerbit:Nature Communications
Tahun:21 September 2010
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Baca Artikel:Es Sebagai Media Protoseluler Replikasi RNA Asal-Usul Kehidupan